We present three experiments using a novel problem in which participants update their estimates of propensities when faced with an uncertain new instance. We examine this using two different causal structures (common cause/common effect) and two different scenarios (agent‐based/mechanical). In the first, participants must update their estimate of the propensity for two warring nations to successfully explode missiles after being told of a new explosion on the border between both nations. In the second, participants must update their estimate of the (...) accuracy of two early warning tests for cancer when they produce conflicting reports about a patient. Across both experiments, we find two modal responses, representing around one‐third of participants each. In the first, “Categorical” response, participants update propensity estimates as if they were certain about the single event, for example, certain that one of the nations was responsible for the latest explosion, or certain about which of the two tests is correct. In the second, “No change” response, participants make no update to their propensity estimates at all. Across the three experiments, the theory is developed and tested that these two responses in fact have a single representation of the problem: because the actual outcome is binary (only one of the nations could have launched the missile; the patient either has cancer or not), these participants believe it is incorrect to update propensities in a graded manner. They therefore operate on a “certainty threshold” basis, whereby, if they are certain enough about the single event, they will make the “Categorical” response, and if they are below this threshold, they will make the “No change” response. Ramifications are considered for the “categorical” response in particular, as this approach produces a positive‐feedback dynamic similar to that seen in the belief polarization/confirmation bias literature. (shrink)

Does George Berkeley provide an argument for the existence of the Judeo-Christian God at Principles of Human Knowledge, part I, section 29? The standard answer is that he does. In this paper, we challenge that interpretation. First, we look at section 29 in the context of its preceding sections and argue that the most the argument establishes is that there are at least two minds, that is, that the thesis of solipsism is false. Next, we examine the argument in section (...) 29 in light of the conclusions Berkeley draws in sections 30–33. There Berkeley concludes that there is one cause of the ordered world of ideas, a cause he calls the "Author of Nature." We argue that Berkeley's Author of Nature is conceptually distinct from, although numerically identical with, the Judeo-Christian God, for whose existence Berkeley argues in section 146. Finally, we ask whether, if our conclusion is correct, it is significant that Berkeley drew a conceptual distinction between the Author of Nature and the Judeo-Christian God. (shrink)

Malignant cells are characterized by an increased content of endogenous formaldehyde formed as a by‐product of biosynthetic processes. Accumulation of formaldehyde in cancer cells is combined with activation of the processes of cellular formaldehyde clearance. These mechanisms include increased ALDH and suppressed ADH5/FDH activity, which oncologists consider poor and favorable prognostic markers, respectively. Here, the sources and regulation of formaldehyde metabolism in cancer cells are reviewed. The authors also analyze the participation of oncoproteins such as fibulins, FGFR1, HER2/neu, FBI‐1, and (...) MUC1‐C in the control of genes related to formaldehyde metabolism, suggesting the existence of two mutually exclusive processes in cancer cells: 1) production and 2) oxidation and elimination of formaldehyde from the cell. The authors hypothesize that the study of the anticancer properties of disulfiram and alpha lipoic acid – which affect the balance of formaldehyde in the body – may serve as the basis of future anticancer therapy. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy and Rhetoric 37.1 (2004) 1-20 [Access article in PDF] Endoxa, Epistemological Optimism, and Aristotle's Rhetorical Project Ekaterina V. Haskins Communication Department Boston College Aristotle's crucial role in institutionalizing the art of rhetoric in the fourth century BCE is beyond dispute, but the significance of Aristotle's rhetorical project remains a point of lively controversy among philosophers and rhetoricians alike. There are many ways of reading and evaluating Aristotle's (...) Rhetoric that depend on the philosophical, theoretical, and pedagogical purposes of the scholar.1 Most philosophical and rhetorical exegeses of the Rhetoric, however, while focusing on the text's connections to Aristotle's corpus and to the rhetorical tradition before and after Aristotle, seem to lack a critical perspective on Aristotle's relationship with his cultural context. Yet, like other parts of Aristotle's encyclopedic intellectual endeavor, much of Rhetoric 's cultural content was provided by endoxa, "reputable or received opinions."Since G. E. L. Owen's essay "Tithenai ta phainomena" (1961) many scholars have accepted the claim that endoxa, rather than empirical observations, are the source of Aristotle's own philosophical principles. The "linguistic" turn within Aristotelian studies has drawn attention to the role of "facts" of language and ordinary experience within Aristotle's philosophical method. As a result, a view of Aristotle as a hard-core empiricist has given way to a picture of a humanist who is attuned to the nuances of his cultural milieu. Still, this new portrait fails to take into account that Aristotle's manner of selecting and categorizing his linguistic resources allows him to transform what we would consider cultural beliefs into natural, and hence, atemporal premises. This pattern can be explained by Aristotle's "epistemological optimism," in itself a blend of several cultural assumptions about perception in general and vision in particular, the function of language, and the cyclical nature of human history. Part of this essay's objective, then, will be an explanation of these components of Aristotle's epistemological optimism. By appreciating Aristotle's difference [End Page 1] on these issues from our modern assumptions, we will be in a better position to understand why Aristotle relies on endoxa on all three levels of philosophical discourse (theoretical science, moral philosophy, and productive arts of poetics and rhetoric). Aristotle remains consistent in his treatment of endoxa throughout; rhetoric, however, presents a major challenge to Aristotle's epistemological optimism and his conception of language. I shall argue that Aristotle recognized this challenge and that he answered it by isolating proofs and rhetorical genres from their linguistic medium (lexis ), and postulating linguistic transparency (sapheneia ) as a stylistic norm. I. Aristotle's openness to appearances (phainomena ) and opinions (endoxa ) was accorded prominence especially thanks to the work of G. E. L. Owen and Martha Nussbaum. Owen was first to defend a linguistic translation of Aristotle's phainomena as "ordinary beliefs" and "appearances" against the then-prevalent rendition "observed facts." In so doing he asserted the crucial impact of the philosopher's cultural context on the formation of speculative discourse. Owen (1961) nonetheless demanded that phainomena be understood as empirical observations in Aristotle' treatises on biology and meteorology (84-86), so as to preserve the methodological and epistemological distinctions between inquiries into the natural world, on the one hand, and the world inhabited by human agents, on the other. Nussbaum (1986) went much further than Owen in asserting the role of phainomena and endoxa in Aristotle's inquiry. Unlike Owen, Nussbaum sees no fundamental difference between "experiences" of a philosopher and linguistic expressions of cultural beliefs and interpretations—his discursive data—from which Aristotle constructs his philosophical accounts. Nussbaum's chief (and highly influential) claim is that Aristotle's method is marked by a deep concern for the experiential world of his fellow men and their language. Aristotle's philosophical insights into the human condition, on this reading, echo and amplify classical Greek tragedy, despite the austere diction of Aristotle's extant treatises.Owing to this openness to the world of ordinary beliefs, Aristotle seems to depart from the Eleatic and Platonic distrust of human... (shrink)

LetEbe a computably enumerable equivalence relation on the setωof natural numbers. We say that the quotient set$\omega /E$realizesa linearly ordered set${\cal L}$if there exists a c.e. relation ⊴ respectingEsuch that the induced structure is isomorphic to${\cal L}$. Thus, one can consider the class of all linearly ordered sets that are realized by$\omega /E$; formally,${\cal K}\left = \left\{ {{\cal L}\,|\,{\rm{the}}\,{\rm{order}}\, - \,{\rm{type}}\,{\cal L}\,{\rm{is}}\,{\rm{realized}}\,{\rm{by}}\,E} \right\}$. In this paper we study the relationship between computability-theoretic properties ofEand algebraic properties of linearly ordered sets realized (...) byE. One can also define the following pre-order$ \le _{lo} $on the class of all c.e. equivalence relations:$E_1 \le _{lo} E_2 $if every linear order realized byE1is also realized byE2. Following the tradition of computability theory, thelo-degrees are the classes of equivalence relations induced by the pre-order$ \le _{lo} $. We study the partially ordered set oflo-degrees. For instance, we construct various chains and anti-chains and show the existence of a maximal element among thelo-degrees. (shrink)

Personal data use is increasingly permeating our everyday life. Informed consent for personal data use is a central instrument for ensuring the protection of personal data. However, current informed consent practices often fail to actually inform data subjects about the use of personal data. This article presents the results of a requirements analysis for informed consent from both a legal and usability perspective, considering the application context of educational assessment. The requirements analysis is based on European Union law and a (...) review of current practices. As the main outcome, the article presents a blueprint which will be the basis for the development of an informed consent template that supports data controllers in establishing an effective and efficient informed consent form. Because the blueprint, and subsequently, the template, distinguishes between legal and usability requirements, it also provides the basis for the mapping of legal requirements in other contexts. (shrink)

Defining the degree of categoricity of a computable structure ${\mathcal{M}}$ to be the least degree d for which ${\mathcal{M}}$ is d-computably categorical, we investigate which Turing degrees can be realized as degrees of categoricity. We show that for all n, degrees d.c.e. in and above 0 (n) can be so realized, as can the degree 0 (ω).

In the current debate there are two epistemological approaches to the definition of ignorance: the Standard View and the New View. The former defines ignorance simply as not knowing, while the latter defines it as the absence of true belief. One of the main differences between these two positions lies in rejecting (Standard View) or in accepting (New View) the factivity of ignorance, i.e., if an agent is ignorant of φ, then φ is true. In the present article, we first (...) provide a criticism of the Standard View in favour of the New View. Secondly, we propose a formal setting to represent the notion of factive ignorance. (shrink)

We study the structure of Σ11 equivalence relations on hyperarithmetical subsets of ω under reducibilities given by hyperarithmetical or computable functions, called h-reducibility and FF-reducibility, respectively. We show that the structure is rich even when one fixes the number of properly equation imagei.e., Σ11 but not equation image equivalence classes. We also show the existence of incomparable Σ11 equivalence relations that are complete as subsets of ω × ω with respect to the corresponding reducibility on sets. We study complete Σ11 (...) equivalence relations and show that existence of infinitely many properly Σ11 equivalence classes that are complete as Σ11 sets is necessary but not sufficient for a relation to be complete in the context of Σ11 equivalence relations. (shrink)

RESUMO O uso de linguagem codificada e esópica nos trabalhos dos semioticistas que integraram a Escola Semiótica de Tártu-Mosou foi motivado pelo desejo de serem compreendidos pelo círculo e não compreendidos por possíveis intrusos indesejáveis dos órgãos de controle soviéticos. Um dos termos centrais utilizados pela Escola - os “sistemas modelizantes secundários” - foi sugerido por Vladímir Uspiénski com o objetivo de substituir a palavra "semiótica", associada à semiótica ocidental. Ao cotejar o artigo de Iúri Lotman Sobre o problema da (...) tipologia da cultura, de 1967, com a tradução para o português do Brasil de Lucy Seki, que integrou a coletânea Semiótica Russa, organizada por Boris Schnaiderman, objetivo verificar se as peculiaridades do texto original, que surgiram devido às condições histórico-políticos da sua criação, foram preservadas na tradução. ABSTRACT The use of codified and Aesopian language in the works of the semioticians who were members of the Tartu-Moscow Semiotic School was motivated by the desire to be understood by the School members and notunderstood by possible unwanted intruders from Soviet control organizations. One of the key terms they used was secondary modeling systems, which Vladimir Uspensky suggested to replace the word semiotics, associated with Western semiotics. By comparing Yuri Lotman’s essay Problems in the Typology of Culture to Lucy Seki’s translation of the essay into Brazilian Portuguese, which is part of the book Semiótica Russa [Russian Semiotics], edited by Boris Schnaiderman, I intend to verify if particularities of the original text, which resulted from the historical and political context in which the essay was produced, were maintained in the translation. (shrink)

In recent years, the emergence of a new trend in contemporary philosophy has been observed in the increasing usage of empirical research methods to conduct philosophical inquiries. Although philosophers primarily use secondary data from other disciplines or apply quantitative methods (experiments, surveys, etc.), the rise of qualitative methods (e.g., in-depth interviews, participant observations and qualitative text analysis) can also be observed. In this paper, I focus on how qualitative research methods can be applied within philosophy of science, namely within the (...) philosophical debate on modeling. Specifically, I review my empirical investigations into the issues of model de-idealization, model justification and performativity. (shrink)

In this topical section, we highlight the next step of research on modeling aiming to contribute to the emerging literature that radically refrains from approaching modeling as a scientific endeavor. Modeling surpasses “doing science” because it is frequently incorporated into decision-making processes in politics and management, i.e., areas which are not solely epistemically oriented. We do not refer to the production of models in academia for abstract or imaginary applications in practical fields, but instead highlight the real entwinement of science (...) and policy and the real erosion of their boundaries. Models in decision making – due to their strong entwinement with policy and management – are utilized differently than models in science; they are employed for different purposes and with different constraints. We claim that “being a part of decision-making” implies that models are elements of a very particular situation, in which knowledge about the present and the future is limited but dependence of decisions on the future is distinct. Emphasis on the future indicates that decisions are made about actions that have severe and lasting consequences. In these specific situations, models enable not only the acquisition of knowledge (the primary goal of science) but also enable deciding upon actions that change the course of events. As a result, there are specific ways to construct effective models and justify their results. Although some studies have explored this topic, our understanding of how models contribute to decision making outside of science remains fragmentary. This topical section aims to fill this gap in research and formulate an agenda for additional and more systematic investigations in the field. (shrink)

The proliferation of digital technologies is precipitating a transformation in the socio-cultural fabric of human existence. The present study is dedicated to investigating the coexistence of various reading practices among contemporary youth in the modern era. The advent of new forms of reading has resulted in a shift from conventional paper-based reading to electronic formats, which, in turn, has transformed the practice of reading and the way of life associated with it. The methodological foundation of this research is the socio-philosophical (...) theory that the practice of reading, rooted in the habitus of reading, is enacted by practitioners, and organized through public initiatives. The context of the reading practice system is a distinct historical system of circumstances in which practices are reproduced. This study encompasses an empirical component, focusing on the examination of reading practices among young individuals in a large modern city, specifically within the confines of Yekaterinburg (N = 200). The research was conducted between December 2021 and January 2022. This study permits an analysis of the constituent elements of the reader’s habitus model as a form of life. (shrink)

Primary headaches are highly prevalent and represent a major cause of disability in young adults. Neurofeedback is increasingly used in the treatment of chronic pain; however, there are few studies investigating its efficacy in patients with headaches. We report the results of a cross-over sham-controlled study on the efficacy of neurofeedback in the prophylactic treatment of tension-type headache. Participants received ten sessions of infra-low frequency electroencephalographic neurofeedback and ten sessions of sham-neurofeedback, with the order of treatments being randomized. The study (...) also included a basic psychotherapeutic intervention — a psychoeducational session performed before the main study phases and emotional support provided throughout the study period. The headache probability was modeled as a function of the neurofeedback and sham-neurofeedback sessions performed to date. As a result, we revealed a strong beneficial effect of neurofeedback and no influence of the sham sessions. The study supports the prophylactic use of infra-low frequency neurofeedback in patients with TTH. From a methodological point of view, we advocate for the explicit inclusion of psychotherapeutic components in neurofeedback study protocols. (shrink)

This is a review of the book by E.G. Dragalina-Chyornaya “Informal notes on logical form". The review discusses the structure and the main ideas of the book. The review focuses on the author's arguments in favor of the dynamic regulatory model of logic and provides a critical analysis of them.

Background Autism self-advocates’ views regarding genetic tests for autism are important, but critical questions about their perspectives arise.Methods We interviewed 11 autism self-advocates, recruited through autism self-advocacy websites, for 1 h each.Results Interviewees viewed genetic testing and its potential pros and cons through the lens of their own indiviudal perceived challenges, needs and struggles, especially concerning stigma and discrimination, lack of accommodations and misunderstandings from society about autism, their particular needs for services, and being blamed by others and by themselves (...) for autistic traits. Their views of genetic testing tended not to be binary, but rather depended on how the genetic test results would be used. Interviewees perceived pros of genetic testing both in general and with regard to themselves (e.g., by providing “scientific proof” of autism as a diagnosis and possibly increasing availability of services). But they also perceived disadvantages and limitations of testing (e.g., possible eugenic applications). Participants distinguished between what they felt would be best for themselves and for the autistic community as a whole. When asked if they would undergo testing for themselves, if offered, interviewees added several considerations (e.g., undergoing testing because they support science in general). Interviewees were divided whether a genetic diagnosis would or should reduce self-blame, and several were wary of testing unless treatment, prevention or societal attitudes changed. Weighing these competing pros and cons could be difficult.Conclusions This study, the first to use in-depth qualitative interviews to assess views of autism self-advocates regarding genetic testing, highlights key complexities. Respondents felt that such testing is neither wholly good or bad in itself, but rather may be acceptable depending on how it is used, and should be employed in beneficial, not harmful ways. These findings have important implications for practice, education of multiple stakeholders, research, and policy. (shrink)

Here, the emerging data on DNA G‐quadruplexes (G4s) as epigenetic modulators are reviewed and integrated. This concept has appeared and evolved substantially in recent years. First, persistent G4s (e.g., those stabilized by exogenous ligands) were linked to the loss of the histone code. More recently, transient G4s (i.e., those formed upon replication or transcription and unfolded rapidly by helicases) were implicated in CpG island methylation maintenance and de novo CpG methylation control. The most recent data indicate that there are direct (...) interactions between G4s and chromatin remodeling factors. Finally, multiple findings support the indirect participation of G4s in chromatin reshaping via interactions with remodeling‐related transcription factors (TFs) or damage responders. Here, the links between the above processes are analyzed; also, how further elucidation of these processes may stimulate the progress of epigenetic therapy is discussed, and the remaining open questions are highlighted. (shrink)

In August 2021, Froese et al. published survey data collected from 2,543 respondents on their subjective experiences living under imposed social distancing measures during COVID-19 (1). The questionnaire was issued to respondents in the UK, Japan, and Mexico. By combining the authors’ expertise in phenomenological philosophy, phenomenological psychopathology, and enactive cognitive science, the questions were carefully phrased to prompt reports that would be useful to phenomenological investigation and theorizing (2–4). These questions reflected the various author’s research interests (e.g., technology, grief, (...) time). Between April 7th and July 31st, 2021, a second questionnaire with the same question set was issued to respondents of the original who had agreed to do a follow-up. This was intended to capture subjective reports of life under social distancing measures a year after the initial survey. By this time–depending on their country of residence and health status–respondents had potentially lived with repeated and prolonged lockdowns and a variety of other restrictions on their social lives. When taken together, Survey I and Survey II provide a cross-cultural and longitudinal dataset that allows for analysis of longer-term impacts of imposed social distancing measures on people’s experiences. For researchers working in diverse disciplines, this dataset offers a rich resource that reflects people’s reactions to the imposition of different social restrictions in different countries and over different time periods. (shrink)

We investigate the complexity of embeddings between bi-embeddable structures. In analogy with categoricity spectra, we define the bi-embeddable categoricity spectrum of a structure A as the family of Turing degrees that compute embeddings between any computable bi-embeddable copies of A; the degree of bi-embeddable categoricity of A is the least degree in this spectrum (if it exists). We extend many known results about categoricity spectra to the case of bi-embeddability. In particular, we exhibit structures without degree of bi-embeddable categoricity, and (...) we show that every degree d.c.e above 0(α) for α a computable successor ordinal and 0(λ) for λ a computable limit ordinal is a degree of bi-embeddable categoricity. We also give examples of families of degrees that are not bi-embeddable categoricity spectra. (shrink)

Taking an abductive, mixed-methods approach, we explore the content of people’s moral deliberations. In Study 1, we gather qualitative data from small groups of graduate business students discussing moral dilemmas. We analyze their conversations with a focus on how participants perceive others’ thoughts, opinions, and evaluations about the dilemmas and incorporate them into their reasoning. Ascribing such capacities to think and feel to others—i.e., mind perception—is central to morality. We use the conversations in Study 1 to identify whose minds participants (...) perceive. Study 1 also identifies how particular elements of deliberation—including the exploration of consequences, acknowledging ambivalence, seeking alternative options, the development of deep feelings, and the search for a moral compass—are linked to these perceptions of others’ minds. In Study 2 (an exploratory, online experiment with 378 participants), we find that priming individuals with specific forms of mind perception can influence the elements of moral reasoning they employ, and we find evidence that the presence of elements of reasoning are linked to participants’ final choices in a business-related ethical dilemma. (shrink)

Ekaterina II (romanized)--Denis Diderot.--Didro v gosti︠a︡kh u Ekaterina (romanized)--Prilozhenii︠a︡ (romanized)--Primi︠e︡chanii︠a︡ (romanized).

Growing concern has been expressed that we have entered a “post-truth” era in which each of us willfully believes whatever we choose, aided and abetted by alternative and social media that spin alternative realities for boutique consumption. A prime example of the belief in alternative realities is said to be acceptance of “conspiracy theories”—a term that is often used as a pejorative to indict claims of conspiracy that are so obviously absurd that only the unhinged could believe them. The epistemological (...) standard often involved in this indictment, however—the standard of “obvious” falsity—invites subjectivity in its application, because what is obviously false to one person can be common sense to another. This is not just a truism; considerable research suggests that people’s political beliefs, in general, and their acceptance or rejection of conspiracy theories in particular, tends in large part to be determined by partisan, ideological, and other priors. (shrink)

The title of this paper reflects the fact truthmaking is quite frequently considered to be expressive of realism. What this means, exactly, will become clearer in the course of our discussion, but since we are interested in Armstrong’s work on truthmaking in particular, it is natural to start from a brief discussion of how truthmaking and realism appear to be associated in his work. In this paper, special attention is given to the supposed link between truthmaking and realism, but it (...) is argued that this link should not be taken too seriously, as truthmaking turns out to be, to a large extent, ontologically neutral. Some consequences of this are studied. (shrink)

It is now possible to have a child without sexual intercourse. The history of this apparently new statement has been breefly synthetised.The new perspectives open ethical problems for the scientific community and a new social context for single women.

The main aim of this paper is to introduce the logics of evidence and truth $$LET_{K}^+$$ and $$LET_{F}^+$$ together with sound, complete, and decidable six-valued deterministic semantics for them. These logics extend the logics $$LET_{K}$$ and $$LET_{F}^-$$ with rules of propagation of classicality, which are inferences that express how the classicality operator $${\circ }$$ is transmitted from less complex to more complex sentences, and vice-versa. The six-valued semantics here proposed extends the 4 values of Belnap-Dunn logic with 2 more values (...) that intend to represent (positive and negative) reliable information. A six-valued non-deterministic semantics for $$LET_{K}$$ is obtained by means of Nmatrices based on swap structures, and the six-valued semantics for $$LET_{K}^+$$ is then obtained by imposing restrictions on the semantics of $$LET_{K}$$. These restrictions correspond exactly to the rules of propagation of classicality that extend $$LET_{K}$$. The logic $$LET_{F}^+$$ is obtained as the implication-free fragment of $$LET_{K}^+$$. We also show that the 6 values of $$LET_{K}^+$$ and $$LET_{F}^+$$ define a lattice structure that extends the lattice L4 defined by the Belnap-Dunn four-valued logic with the 2 additional values mentioned above, intuitively interpreted as positive and negative reliable information. Finally, we also show that $$LET_{K}^+$$ is Blok-Pigozzi algebraizable and that its implication-free fragment $$LET_{F}^+$$ coincides with the degree-preserving logic of the involutive Stone algebras. (shrink)